This is quite a late model question for me , however, as we are still doing later systems in our new world there is some basic guidance. The real answer to this one is to see the engine data. It has a good chance to cope with those changes, with knock sensors protecting and lambda adjusting fuel as needed. However , the issue is with any ethanol included it needs to add much more fuel generally. And then it depends on latitude the lambda has at its disposal to add more fuel. That will be in the specific calibration. So seeing the engine data is the only safe way to be sure it’s protected.
So it’s a risk evaluation. The risk maybe mitigated if you stay with fuel you have used so far, that cost and irritation may be better than losing a piston?